Interferon-Inducible Gene Expression Signature in Peripheral Blood Cells of Patients with Severe SLE

E. Baechler, F. Batliwalla, G. Karypis, P. Gaffney, W. Ortmann, K. Espe, K. Shark, W. Grande, K. Hughes, V. Kapur, P. Gregersen, and T. Behrens
Proceedings of the National Academies of Sciences (PNAS), Vol. 100, No. 5, pp. 2610 - 2615, 2003
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Systemic lupus erythematosus (SLE) is a complex, inflammatory
autoimmune disease that affects multiple organ systems. We used
global gene expression profiling of peripheral blood mononuclear
cells to identify distinct patterns of gene expression that distinguish
most SLE patients from healthy controls. Strikingly, about
half of the patients studied showed dysregulated expression of
genes in the IFN pathway. Furthermore, this IFN gene expression
signature served as a marker for more severe disease involving
the kidneys, hematopoetic cells, andor the central nervous system.
These results provide insights into the genetic pathways
underlying SLE, and identify a subgroup of patients who may
benefit from therapies targeting the IFN pathway.
Research topics: Bioinformatics