consensus clustering using scluster


I wish to use scluster command-line tool (or API) to get consensus clustering from two NxN pair-wise similarity matrices. The two similarity matrices have been generated using different methods for same sets of objects. To be more specific, I have pair-wise similarity matrices for N chemical compounds calculated using: (i) Circular Fingerprints and tanimoto coefficient (0-1), (ii) Tanimoto coefficient of continuous valued theoretical descriptors (0-1).

I am using scluster with following settings for each similarity matrices:

-nclusters varied from 2 to 300

I collect all the cluster solution for various K-ways clustering, extract unique solutions, and do machine learning exercise on the obtained clusters.

Any help regarding usage of scluster for arriving consensus clustering, would be greatly appreciated.

Om Prakash
Ph.D Student
School of Computational and Integrative Sciences,
Jawaharlal Nehru University,
New Delhi,